Vitamin C is incompatible in solution with Aminophylline, Bleomycin, Erythromycin, Lactobionate, Nafcillin, Nitrofurantoin Sodium, Conjugated oestrogens, Sodium bicarbonate, Salphafurazole diethanolamine, Chloramphenicol sodium succinate, Chlorthiazide sodium and Hydrocortisone sodium succinate. It increases the apparent half life of Paracetamol and enhances iron absorption from the gastrointestinal tract. No potentially useful drug Interaction with Vitamin E has been described. However, high doses of Vitamin E can impair intestinal absorption of Vitamin A and K.

Thiazide diuretics reduce the urinary excretion of calcium. Due to increased risk of hypercalcaemia, serum calcium should be regularly monitored during concomitant use of thiazide diuretics. Systemic corticosteroids reduce calcium absorption. During concomitant use, it may be necessary to increase the dose of calcium tablet. Simultaneous treatment with ion exchange resins such as cholestyramine or laxatives such as paraffin oil may reduce the gastrointestinal absorption of vitamin D. Calcium carbonate may interfere with the absorption of concomitantly administered tetracycline preparations. For this reason, tetracycline preparations should be administered at least two hours before, or four to six hours after, oral intake of calcium. Hypercalcaemia may increase the toxicity of cardiac glycosides during treatment with calcium and vitamin D. Patients should be monitored with regard to electrocardiogram (ECG) and serum calcium levels. If a bisphosphonate or sodium fluoride is used concomitantly, Seacal-D should be administered at least three hours before the intake of calcium tablet since gastrointestinal absorption may be reduced. Oxalic acid (found in spinach and rhubarb) and phytic acid (found in whole cereals) may inhibit calcium absorption through formation of insoluble calcium salts. The patient should not take calcium products within two hours of eating foods high in oxalic acid and phytic acid.