As with other non-selective NSAIDs, naproxen exerts it’s clinical effects by blocking COX-1 and COX-2 enzymes leading to decreased prostaglandin synthesis. Although both enzymes contribute to prostaglandin production, they have unique functional differences. The COX-1 enzymes is constitutively active and can be found in normal tissues such as the stomach lining, while the COX-2 enzyme is inducible and produces prostaglandins that mediate pain, fever and inflammation. The COX-2 enzyme mediates the desired antipyretic, analgesic and anti-inflammatory properties offered by Naproxen, while undesired adverse effects such as gastrointestinal upset and renal toxicities are linked to the COX-1 enzyme.

Beta carotene of this tablet is converted to vitamin A (Retinol) when required. Retinol has several biochemical functions e.g. on retina, growth, tissue differentiation, immunological response. It has also some anti-cancer activity.

Vitamin C is the most powerful reducing agent known to be present in living tissues. Vitamin C deficiency produces scurvy. It is a cofactor in numerous biological processes. Vitamin C and molecular oxygen are essential for the conversion of proline to hydroxyproline, dopamine to noradrenaline . Vitamin C is also essential for the synthesis of adrenal steroid hormones. Vitamin C is important in the defense against infection and studies shown that vitamin C is important for the normal functioning of T-lymphocyte and leukocyte. Ascorbic acid has some antiinflammatory activity and protects cells against oxidation of essential molecules. In high doses, (1-2 g daily) ascorbic acid increases iron absorption.

vitamin E seems to be as a defense against oxidative stress and lipid peroxidation. In most cell membranes there is one molecule of tocopherol for every 1000 lipid molecules. Tocopherol mops up peroxide radicals and then needs a supply of reduced hydrogen to restore the steady-state situation. This is usually supplied by ascorbic acid or reduced glutathione.

This is an antioxidant vitamins capsule containing Vitamin (Vitamin-C, Vitamin-E), Minerals (Zinc, Copper) and Lutein for oral administration.

The formulation contains essential antioxidant vitamins, minerals and Lutein. Vitamin-C is highly concentrated in the lens compared to blood. Long term use of Vitamin-C supplement (10+ years) has been associated with reduced risk of cataract. It has important role in harmful free radicals scavenge activity.

In study, it is found that high serum Vitamin-E concentrations have been associated with reduced risk of cataract (exact mechanism of action is not still established).

Lutein is a carotenoid specially concentrated in macula. Clinical and animal data indicate that this carotenoid could protect the macula from oxidative or light damage. Although mechanism of action is not clear but one large study has found that high levels of dietary Lutein are associated with relatively lower risk of AMD (Age-Related Macular Degeneration: a condition where fine visual activity is lost).

Zinc is an essential trace element involved in many enzyme systems. Symptoms of less severe deficiency include distorted or absent perception of taste, smell and poor wound healing. Severe deficiency causes skin lesion, alopecia, diarrhea, increased susceptibility to infection and failure to thrive in children.

Copper plays an important role in growth, skeletal integrity and development of nervous system. As a part of various enzymes, it takes part of numerous metabolic conversions.